Aphasia Neuroplasticity Review

van de Sandt-Koenderman et al. (2018)

Reference

Authorsvan de Sandt-Koenderman, MWME; Orellana, CPM; van der Meulen, I; Smits, M; Ribbers, GM
TitleLanguage lateralisation after Melodic Intonation Therapy: an fMRI study in subacute and chronic aphasia
ReferenceAphasiology 2018; 32: 765-783
PMIDN/A
DOI10.1080/02687038.2016.1240353

Participants

LanguageDutch
Inclusion criteriaSevere non-fluent aphasia (< 50 words/minute); articulation deficits; repetition severely affected; moderate-good auditory comprehension
Number of individuals with aphasia9
Number of control participants0
Were any of the participants included in any previous studies?No
Is age reported for patients and controls, and matched?Yes (subacute: mean 51.2 years, range 25-61 years; chronic: mean 54.0 years, range 21-66 years)
Is sex reported for patients and controls, and matched?Yes (males: 5; females: 4)
Is handedness reported for patients and controls, and matched?Yes (right: 8; left: 0; other: 1)
Is time post stroke onset reported and appropriate to the study design?Yes (subacute: range 0.5-3 months; chronic: range 17-40 months)
To what extent is the nature of aphasia characterized?Comprehensive battery
Language evaluationAAT, ANELT
Aphasia severityT1: subacute: ASRS median 1, range 0-2; ANELT range 10-29; chronic: ASRS median 1.5, range 1-2; ANELT range 20-29; T2: subacute: ASRS range 1-3; ANELT range 10-43; chronic: ASRS range 1-2; ANELT range 22-31
Aphasia typeT1: all severe non-fluent; T2: not stated
First stroke only?Not stated
Stroke typeNot stated
To what extent is the lesion distribution characterized?Extent and location
Lesion extentSubacute: range 32.4-141.2 cc (no lesion extent was reported for one subacute participant because there was no tissue loss yet); chronic: range 27.4-87.9 cc
Lesion location8 L MCA, 1 L SMA and R insular-temporoparietal
Participants notes

Imaging

ModalityfMRI
Is the study cross-sectional or longitudinal?Longitudinal—mixed
If longitudinal, at what time point(s) were imaging data acquired?T1: pre treatment/subacute or chronic; T2: post-treatment, ~6 weeks later
If longitudinal, was there any intervention between the time points?MIT, 5+ hours/week
Is the scanner described?No (GE 3 Tesla; model not stated)
Is the timing of stimulus presentation and image acquisition clearly described and appropriate?Yes
Design typeBlock
Total images acquired132
Are the imaging acquisition parameters, including coverage, adequately described and appropriate?Yes (whole brain)
Is preprocessing and intrasubject coregistration adequately described and appropriate?Yes
Is first level model fitting adequately described and appropriate?Yes
Is intersubject normalization adequately described and appropriate?No (lesion impact not addressed)
Imaging notes

Conditions

Are the conditions clearly described?Yes
ConditionResponse typeRepetitionsAll groups could do?All individuals could do?
listening to narrative speechNone6N/AN/A
listening to reversed speechNone6N/AN/A
Conditions notes

Contrasts

Are the contrasts clearly described?Yes

Contrast 1: listening to narrative speech vs listening to reversed speech

Language conditionListening to narrative speech
Control conditionListening to reversed speech
Are the conditions matched for visual demands?Yes
Are the conditions matched for auditory demands?Yes
Are the conditions matched for motor demands?Yes
Are the conditions matched for cognitive/executive demands?Yes
Is accuracy matched between the language and control tasks for all relevant groups?N/A, no behavioral measure
Is reaction time matched between the language and control tasks for all relevant groups?N/A, no timeable task
Behavioral data notes
Are control data reported in this paper or another that is referenced?No
Does the contrast selectively activate plausible relevant language regions in the control group?Unknown
Are activations lateralized in the control data?Unknown
Control activation notes
Contrast notes

Analyses

Are the analyses clearly described?No* (moderate limitation) (see specific limitation(s) below)

ROI analysis 1

First level contrastListening to narrative speech vs listening to reversed speech
Analysis classCross-sectional correlation with language or other measure
Group(s)Aphasia T1
CovariateLesion volume
Is the second level contrast valid in terms of the group(s), time point(s), and measures involved?Yes
Is accuracy matched across the second level contrast?N/A, no behavioral measure
Is reaction time matched across the second level contrast?N/A, no timeable task
Behavioral data notes
Type of analysisRegion of interest (ROI)
ROI typeLaterality indi(ces)
How many ROIs are there?1
What are the ROI(s)?Language network LI
How are the ROI(s) defined?Activations that were "not clearly related to known language areas" were excluded, but the basis for this determination is not clear
Correction for multiple comparisonsOne only
Statistical details
FindingsNone
Findings notes

ROI analysis 2

First level contrastListening to narrative speech vs listening to reversed speech
Analysis classLongitudinal correlation with language or other measure
Group(s)Aphasia T2 vs T1
CovariateLesion volume
Is the second level contrast valid in terms of the group(s), time point(s), and measures involved?Yes
Is accuracy matched across the second level contrast?N/A, no behavioral measure
Is reaction time matched across the second level contrast?N/A, no timeable task
Behavioral data notes
Type of analysisRegion of interest (ROI)
ROI typeLaterality indi(ces)
How many ROIs are there?1
What are the ROI(s)?Language network LI
How are the ROI(s) defined?Activations that were "not clearly related to known language areas" were excluded, but the basis for this determination is not clear
Correction for multiple comparisonsOne only
Statistical details
FindingsNone
Findings notes

ROI analysis 3

First level contrastListening to narrative speech vs listening to reversed speech
Analysis classLongitudinal correlation with language or other measure
Group(s)Aphasia T2 vs T1
CovariateΔ AAT repetition score
Is the second level contrast valid in terms of the group(s), time point(s), and measures involved?Yes
Is accuracy matched across the second level contrast?N/A, no behavioral measure
Is reaction time matched across the second level contrast?N/A, no timeable task
Behavioral data notes
Type of analysisRegion of interest (ROI)
ROI typeLaterality indi(ces)
How many ROIs are there?1
What are the ROI(s)?Language network LI
How are the ROI(s) defined?Activations that were "not clearly related to known language areas" were excluded, but the basis for this determination is not clear
Correction for multiple comparisonsOne only
Statistical details
FindingsNone
Findings notes

ROI analysis 4

First level contrastListening to narrative speech vs listening to reversed speech
Analysis classLongitudinal correlation with language or other measure
Group(s)Aphasia T2 vs T1
CovariateΔ ANELT
Is the second level contrast valid in terms of the group(s), time point(s), and measures involved?Yes
Is accuracy matched across the second level contrast?N/A, no behavioral measure
Is reaction time matched across the second level contrast?N/A, no timeable task
Behavioral data notes
Type of analysisRegion of interest (ROI)
ROI typeLaterality indi(ces)
How many ROIs are there?1
What are the ROI(s)?Language network LI
How are the ROI(s) defined?Activations that were "not clearly related to known language areas" were excluded, but the basis for this determination is not clear
Correction for multiple comparisonsOne only
Statistical details
FindingsNone
Findings notes

Notes

Excluded analysesIndividual participant LIs and activation maps